Through its commitment to applied research and public health impact, the Fondation Congolaise pour la Recherche Médicale (FCRM) has led and contributed to numerous projects aimed at addressing major health challenges in Central Africa. These initiatives span clinical research, disease surveillance, community-based interventions, and health system strengthening. Each project reflects FCRM’s mission to generate evidence-based solutions, foster innovation, and support national and regional efforts to control and eliminate neglected tropical diseases. The following projects highlight the Foundation’s diverse contributions to advancing scientific knowledge and improving population health.